Chunnel vision

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Chunnel vision

The Escherichia coli TolC protein is central to toxin export and drug efflux across the inner and outer cell membranes and the intervening periplasmic space. The crystal structure has revealed that TolC assembles into a remarkable α-helical trans-periplasmic cylinder (tunnel) embedded in the outer membrane by a contiguous β-barrel (channel), so providing a large duct open to the outside environ...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2000

ISSN: 1469-221X,1469-3178

DOI: 10.1093/embo-reports/kvd075